Synapse Elimination and Indelible Memory
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Synapse Elimination and Indelible Memory
where one, or at most a few, identifiable motor neurons innervate each identifiable muscle fiber, forming a stereotyped circuit exclusively dedicated to a particular Jeff W. Lichtman*‡ and Howard Colman† *Department of Anatomy and Neurobiology †Department of Neurology function (Figure 1). The greater degree of redundancy Washington University School of Medicine is perhaps the most salient diffe...
متن کاملSynapse Elimination Review and Indelible Memory
where one, or at most a few, identifiable motor neurons innervate each identifiable muscle fiber, forming a stereotyped circuit exclusively dedicated to a particular Jeff W. Lichtman*‡ and Howard Colman† *Department of Anatomy and Neurobiology †Department of Neurology function (Figure 1). The greater degree of redundancy Washington University School of Medicine is perhaps the most salient diffe...
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Astrocytes, through their close associations with synapses, can monitor and alter synaptic function, thus actively controlling synaptic transmission in the adult brain. Besides their important role at adult synapses, in the last three decades a number of critical findings have highlighted the importance of astrocytes in the establishment of synaptic connectivity in the developing brain. In this...
متن کاملComment on “Reelin Promotes Peripheral Synapse Elimination
Individual synaptic sites on rodent skeletal muscle fibers are innervated by two or more axons at birth. All inputs but one are then eliminated during the first two postnatal weeks, leaving each muscle fiber singly innervated (1). Quattrocchi et al. (2) reported that polyneuronal innervation of neuromuscular synapses persists well beyond this period in reeler mice (mutant mice lacking Reelin, a...
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The fine tuning of synaptic circuits often requires an activity-dependent phase in which appropriate connections are strengthened and inappropriate connections are eliminated. In this issue of Neuron, Walsh and Lichtman propose a novel "synaptic takeover" mechanism for synapse elimination at the vertebrate NMJ, where withdrawal of one axon is accompanied by expansion of a competing axon into th...
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ژورنال
عنوان ژورنال: Neuron
سال: 2000
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80893-4